Structure of PDB 3en6 Chain B

Receptor sequence
>3en6B (length=239) Species: 9031 (Gallus gallus) [Search protein sequence]
KDAWEIPRESLRLEVKLGQFGEVWMGTWNGTTRVAIKTLAQVMKKLRHEK
LVQLYAVVSIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGM
AYVERMNYVHRDLRAANILVGENLVCKVADFIKWTAPEAALYGRFTIKSD
VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDL
MCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
3D structure
PDB3en6 Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
ChainB
Resolution2.39 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404
Catalytic site (residue number reindexed from 1) D112 R114 A116 N117 D130
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KS5 B V281 A293 K295 T338 Y340 M341 L393 V23 A35 K37 T64 Y66 M67 L119 MOAD: ic50=0.235uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3en6, PDBe:3en6, PDBj:3en6
PDBsum3en6
PubMed18849971
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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