Structure of PDB 3ekq Chain B

Receptor sequence
>3ekqB (length=99) Species: 11685 (HIV-1 M:B_ARV2/SF2) [Search protein sequence]
PQITLWKRPIVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIVGI
GGFVKVRQYDQIPIEICGHKAIGTVLVGPTPTNIIGRNLLTQIGCTLNF
3D structure
PDB3ekq Extreme Entropy-Enthalpy Compensation in a Drug-Resistant Variant of HIV-1 Protease.
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D25 T26 G27
Catalytic site (residue number reindexed from 1) D25 T26 G27
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ROC B R8 L23 D25 G27 V48 P81 I84 R8 L23 D25 G27 V48 P81 I84 PDBbind-CN: -logKd/Ki=6.75,Kd=176.0nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3ekq, PDBe:3ekq, PDBj:3ekq
PDBsum3ekq
PubMed22712830
UniProtP03369|POL_HV1A2 Gag-Pol polyprotein (Gene Name=gag-pol)

[Back to BioLiP]