Structure of PDB 3egi Chain B

Receptor sequence
>3egiB (length=192) Species: 9606 (Homo sapiens) [Search protein sequence]
PLGSRLFSRFDDGIKLDREGWFSVTPEKIAEHIAGRVSQSFKCDVVVDAF
CGVGGNTIQFALTGMRVIAIDIDPVKIALARNNAEVYGIADKIEFICGDF
LLLASFLKADVVFLSPPWAETFDIRTMMSPDGFEIFRLSKKITNNIVYFL
PRNADIDQVASLAGPGGQVEIEQNFLNNKLKTITAYFGDLIR
3D structure
PDB3egi Structure analysis of the conserved methyltransferase domain of human trimethylguanosine synthase TGS1.
ChainB
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B F698 D719 I720 K724 D747 F748 P765 F50 D71 I72 K76 D99 F100 P117
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
Biological Process
GO:0001510 RNA methylation
GO:0036261 7-methylguanosine cap hypermethylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3egi, PDBe:3egi, PDBj:3egi
PDBsum3egi
PubMed19307714
UniProtQ96RS0|TGS1_HUMAN Trimethylguanosine synthase (Gene Name=TGS1)

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