Structure of PDB 3eg9 Chain B

Receptor sequence

>3eg9B (length=767) Species: 9606 (Homo sapiens)

AMGSPIQVIENDRASRGGQVYATNTRGQIPPLVTTDCMIQDQGNASPRFI
RCTTYCFPCTSDMAKQAQIPLAAVIKPFATIPSNESPLYLVNHGESGPVR
CNRCKAYMCPFMQFIEGGRRYQCGFCNCVNDVPPFYFQHLDHIGRRLDHY
EKPELSLGSYEYVATLDYCRKSKPPNPPAFIFMIDVSYSNIKNGLVKLIC
EELKTMLEKIPKEEQEETSAIRVGFITYNKVLHFFNVKSNLAQPQMMVVT
DVGEVFVPLLDGFLVNYQESQSVIHNLLDQIPDMFADSNENETVFAPVIQ
AGMEALKAADCPGKLFIFHSSLPTAEAPGKLKNRDDKKLVNTDKEKILFQ
PQTNVYDSLAKDCVAHGCSVTLFLFPSQYVDVASLGLVPQLTGGTLYKYN
NFQMHLDRQQFLNDLRNDIEKKIGFDAIMRVRTSTGFRATDFFGGILMNN
TTDVEMAAIDCDKAVTVEFKHDDKLSEDSGALIQCAVLYTTISGQRRLRI
HNLGLNCSSQLADLYKSCETDALINFFAKSAFKAVLHQPLKVIREILVNQ
TAHMLACYRKNCASPSAASQLILPDSMKVLPVYMNCLLKNCVLLSRPEIS
TDERAYQRQLVMTMGVADSQLFFYPQLLPIHTLDVKSTMLPAAVRCSESR
LSEEGIFLLANGLHMFLWLGVSSPPELIQGIFNVPSFAHINTDMTLLPEV
GNPYSQQLRMIMGIIQQKRPYSMKLTIVKQREQPEMVFRQFLVEDKGGSS
YVDFLCCVHKEICQLLN

3D structure

• PDB: 3eg9 Structural basis of cargo membrane protein discrimination by the human COPII coat machinery.
• Chain: B
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	M2 S832 Q833 L834 I835 L836 K841 H1025	M2 S569 Q570 L571 I572 L573 K578 H759
BS02	ZN	B	C364 C386	C101 C123

Gene Ontology

Molecular Function

• GO:0008270 zinc ion binding

Biological Process

• GO:0006886 intracellular protein transport
• GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport

Cellular Component

• GO:0030127 COPII vesicle coat

External links

• PDB: RCSB:3eg9, PDBe:3eg9, PDBj:3eg9
• PDBsum: 3eg9
• PubMed: 18843296
• UniProt: O94855|SC24D_HUMAN Protein transport protein Sec24D (Gene Name=SEC24D)