Structure of PDB 3ee6 Chain B

Receptor sequence
>3ee6B (length=529) Species: 9606 (Homo sapiens) [Search protein sequence]
SYSPEPDQRRTLPPGWVSLGRADPEEELSLTFALRQQNVERLSELVQAVS
DPSSPQYGKYLTLENVADLVRPSPLTLHTVQKWLLAAGAQKCHSVITQDF
LTCWLSIRQAELLLPGAEFHHYVGGPTETHVVRSPHPYQLPQALAPHVDF
VGGLHRFPPTSHLGVTPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYF
HDSDLAQFMRLFGGNFAHQASVARVVGQQGRGRAGIEASLDVQYLMSAGA
NISTWVYSSPGRHEGQEPFLQWLMLLSNESALPHVHTVSYGDDEDSLSSA
YIQRVNTELMKAAARGLTLLFASGDSGAGCWSVSGRHQFRPTFPASSPYV
TTVGGTSFQEPFLITNEIVDYISGGGFSNVFPRPSYQEEAVTKFLSSSPH
LPPSSYFNASGRAYPDVAALSDGYWVVSNRVPIPWVSGTSASTPVFGGIL
SLINEHRILSGRPPLGFLNPRLYQQHGAGLFDVTRGCHESCLDEEVEGQG
FCSGPGWDPVTGWGTPNFPALLKTLLNPR
3D structure
PDB3ee6 Structure of tripeptidyl-peptidase I provides insight into the molecular basis of late infantile neuronal ceroid lipofuscinosis
ChainB
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.14.9: tripeptidyl-peptidase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B E137 H155 E118 H136
BS02 ZN B H197 D457 H162 D422
BS03 ZN B E45 H140 H149 E26 H121 H130
BS04 ZN B E424 H511 E389 H476
BS05 CA B D517 V518 G539 P540 G541 D543 D482 V483 G504 P505 G506 D508
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3ee6, PDBe:3ee6, PDBj:3ee6
PDBsum3ee6
PubMed19038966
UniProtO14773|TPP1_HUMAN Tripeptidyl-peptidase 1 (Gene Name=TPP1)

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