Structure of PDB 3e90 Chain B

Receptor sequence
>3e90B (length=173) Species: 11082 (West Nile virus) [Search protein sequence]
GGGVLWDTKEYKKGDTTTGVYRIMTRGLLGSYQAGAGVMVEGVFHTLWHT
TKGAALMSGEGRLDPYWGSVKEDRLCYGGPWKLQHKWNGQDEVQMIVVEP
GKNVKNVRTKPGVFKTPEGEIGAVTLDFPTGTSGSPIVDKNGDVIGLYGN
GVIMPNGSYISAIVQGKRMDEPI
3D structure
PDB3e90 Structure of West Nile virus NS3 protease: ligand stabilization of the catalytic conformation
ChainB
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NKK B H51 D129 F130 G133 S135 G151 N152 G153 Y161 H49 D127 F128 G131 S133 G149 N150 G151 Y159 PDBbind-CN: -logKd/Ki=7.39,Ki=41nM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:3e90, PDBe:3e90, PDBj:3e90
PDBsum3e90
PubMed19059417
UniProtP06935|POLG_WNV Genome polyprotein

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