Structure of PDB 3e7c Chain B

Receptor sequence
>3e7cB (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
LPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAA
VKWAKAIPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQANLLCFAPD
LIINEQRMTLPGMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVP
KDGLKSQELFDEIRMTYIKELGKAIVKSQNWQRFYQLTKLLDSMHEVVEN
LLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ
3D structure
PDB3e7c The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist.
ChainB
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B V575 K579 L589 Q592 M593 L596 Q597 M752 E755 N759 V51 K55 L65 Q68 M69 L72 Q73 M221 E224 N228
BS02 866 B L563 N564 Q570 M604 A607 R611 F623 M639 Q642 Y735 C736 L39 N40 Q46 M80 A83 R87 F97 M113 Q116 Y204 C205 BindingDB: EC50=2nM,IC50=3.16nM
External links
PDB RCSB:3e7c, PDBe:3e7c, PDBj:3e7c
PDBsum3e7c
PubMed18952422
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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