Structure of PDB 3e16 Chain B

Receptor sequence
>3e16B (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
ITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKE
AYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPI
TFSRYIRPISLPAAQASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVP
LISRETCNSLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSC
PVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPR
3D structure
PDB3e16 Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design.
ChainB
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D102
Catalytic site (residue number reindexed from 1) D90
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B4C B H57 E97 G98 P172I H172J F172K A190 Q192 G193 S195 V213 W215 G216 D217 H41 E85 G86 P170 H171 F172 A189 Q191 G192 S194 V212 W214 G215 D216 PDBbind-CN: -logKd/Ki=5.24,Ki=5.78uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3e16, PDBe:3e16, PDBj:3e16
PDBsum3e16
PubMed18752942
UniProtQ16651|PRSS8_HUMAN Prostasin (Gene Name=PRSS8)

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