Structure of PDB 3e12 Chain B

Receptor sequence
>3e12B (length=256) Species: 63363 (Aquifex aeolicus) [Search protein sequence]
KFLVIAGPCAIESEELLLKVGEEIKRLSEKFKEVEFVFKSSFDKANRSSI
HSFRGHGLEYGVKALRKVKEEFGLKITTDIHESWQAEPVAEVADIIQIPA
FLCRQTDLLLAAAKTGRAVNVKKGQFLAPWDTKNVVEKLKFGGAKEIYLT
ERGTTFGYNNLVVDFRSLPIMKQWAKVIYDATHSVQLPGGGMREFIFPLI
RAAVAVGCDGVFMETHPEPEKALSDASTQLPLSQLEGIIEAILEIREVAS
KYYETI
3D structure
PDB3e12 Electronic structure of the metal center in the Cd(2+), Zn(2+), and Cu(2+) substituted forms of KDO8P synthase: implications for catalysis.
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.55: 3-deoxy-8-phosphooctulonate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CU B C11 H185 E222 D233 C9 H183 E214 D225
BS02 PO4 B P101 A102 K124 R154 P99 A100 K122 R152
BS03 KD0 B K41 K46 N48 R49 S50 Q99 K124 H185 D233 K39 K44 N46 R47 S48 Q97 K122 H183 D225 PDBbind-CN: -logKd/Ki=5.99,Kd=1.02uM
Gene Ontology
Molecular Function
GO:0008676 3-deoxy-8-phosphooctulonate synthase activity
GO:0016740 transferase activity
Biological Process
GO:0009058 biosynthetic process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0019294 keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
GO:0046364 monosaccharide biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:3e12, PDBe:3e12, PDBj:3e12
PDBsum3e12
PubMed19228070
UniProtO66496|KDSA_AQUAE 2-dehydro-3-deoxyphosphooctonate aldolase (Gene Name=kdsA)

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