Structure of PDB 3e0p Chain B

Receptor sequence
>3e0pB (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
ITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKE
AYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPI
TFSRYIRPISLPAAQASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVP
LISRETCNSLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSC
PVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQP
3D structure
PDB3e0p Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design.
ChainB
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D102
Catalytic site (residue number reindexed from 1) D90
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B3C B H57 S99 Q100 D102 P172I A190 C191 Q192 G193 S195 V213 S214 W215 G216 D217 A218 H41 S87 Q88 D90 P170 A189 C190 Q191 G192 S194 V212 S213 W214 G215 D216 A217 PDBbind-CN: -logKd/Ki=7.92,Ki=0.012uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3e0p, PDBe:3e0p, PDBj:3e0p
PDBsum3e0p
PubMed18752942
UniProtQ16651|PRSS8_HUMAN Prostasin (Gene Name=PRSS8)

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