Structure of PDB 3e0n Chain B

Receptor sequence
>3e0nB (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
ITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKE
AYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPI
TFSRYIRPISLPAAQASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVP
LISRETCNSLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGGPLSC
PVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPRVVP
Q
3D structure
PDB3e0n Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.
ChainB
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D102
Catalytic site (residue number reindexed from 1) D90
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B H57 G98 S99 E172H P172I D189 A190 C191 Q192 S195 S214 W215 G216 D217 H41 G86 S87 E169 P170 D188 A189 C190 Q191 S194 S213 W214 G215 D216
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3e0n, PDBe:3e0n, PDBj:3e0n
PDBsum3e0n
PubMed19388054
UniProtQ16651|PRSS8_HUMAN Prostasin (Gene Name=PRSS8)

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