Structure of PDB 3e0m Chain B

Receptor sequence
>3e0mB (length=312) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence]
MAEIYLAGGCFWGLEEYFSRISGVLETSVGYANGQVETTNYQLLKETDHA
ETVQVIYDEKEVSLREILLYYFRVIDPLSINQQGNDRGRQYRTGIYYQDE
ADLPAIYTVVQEQERMLGRKIAVEVEQLRHYILAEDYHQDYLRKNPSGYC
HIDVTDADKPLIDAANYEKPSQEVLKASLSEESYRVTQEAATEAPFTNAY
DQTFEEGIYVDITTGEPLFFAKDKFASGCGWPSFSRPLSKELIHYYKDLS
HGMERIEVRSRSGSAHLGHVFTDGPRELGGLRYCINSASLRFVAKDEMEK
AGYGYLLPYLNK
3D structure
PDB3e0m Structural and Kinetic Analysis of an MsrA-MsrB Fusion Protein from Streptococcus pneumoniae
ChainB
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C10 Y41 E51 D86 Y91 C150 K159 C229 H266 H269 D273 R282 C284
Catalytic site (residue number reindexed from 1) C10 Y41 E51 D86 Y91 C150 K159 C229 H266 H269 D273 R282 C284
Enzyme Commision number 1.8.4.11: peptide-methionine (S)-S-oxide reductase.
1.8.4.12: peptide-methionine (R)-S-oxide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B T192 P195 W231 H251 R255 H269 F271 C284 T192 P195 W231 H251 R255 H269 F271 C284
Gene Ontology
Molecular Function
GO:0008113 peptide-methionine (S)-S-oxide reductase activity
GO:0016491 oxidoreductase activity
GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
GO:0033743 peptide-methionine (R)-S-oxide reductase activity
GO:0033744 L-methionine:thioredoxin-disulfide S-oxidoreductase activity
Biological Process
GO:0006979 response to oxidative stress
GO:0030091 protein repair
GO:0036211 protein modification process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3e0m, PDBe:3e0m, PDBj:3e0m
PDBsum3e0m
PubMed19400786
UniProtP0A3Q9|MSAB1_STRPN Peptide methionine sulfoxide reductase MsrA/MsrB 1 (Gene Name=msrAB1)

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