Structure of PDB 3dwr Chain B

Receptor sequence
>3dwrB (length=275) Species: 5664 (Leishmania major) [Search protein sequence]
MSLAVEAVKDFLLKLQDDICEALEAEDGQATFVEDKWTGGRTRVMVDGAV
IEKGGVNFSHVYGCNFEAMGVSLVIHPKNPHVPTSHANVRLFVAEPVWWF
GGGFDLTPYYAVEEDCRDFHQVAQDLCKPFGADVYARFKGWCDEYFFIPY
RNEARGIGGLFFDDLNEWPFEKCFEFVQAVGKGYMDAYIPIVNRRKNTPY
TEQQVEFQEFRRGRYAEFNLVIDRGTKFGLQSGGRTESILISLPPRARWG
YNWQPEPGTPEARLTEYFLTKRQWV
3D structure
PDB3dwr Leishmania major coproporphyrinogen III oxidase with bound ligand
ChainB
Resolution1.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.3.3: coproporphyrinogen oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0PA B V66 S258 I265 V61 S232 I239
BS02 0PA B S93 G251 I265 I267 S72 G225 I239 I241
BS03 0PA B A89 M90 S93 N109 A68 M69 S72 N88
Gene Ontology
Molecular Function
GO:0004109 coproporphyrinogen oxidase activity
GO:0016491 oxidoreductase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:3dwr, PDBe:3dwr, PDBj:3dwr
PDBsum3dwr
PubMed
UniProtP84155|HEM6_LEIMA Oxygen-dependent coproporphyrinogen-III oxidase (Gene Name=LMAJ006828)

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