Structure of PDB 3dsu Chain B

Receptor sequence
>3dsuB (length=325) Species: 10116 (Rattus norvegicus) [Search protein sequence]
QKDVTIKSDAPDTLLLEKHADYIASYGSKKYEYCMSEYLRMSGVYWGLTV
MDLMGQLHRMNKEEILVFIKSCQHECGGVSASIGHDPHLLYTLSAVQILT
LYDSIHVINVDKVVAYVQSLQKEDGSFAGDIWGEIDTRFSFCAVATLALL
GKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQ
LHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLH
WIDREKLRSFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQI
KPVSPVFCMPEEVLQRVNVQPELVS
3D structure
PDB3dsu Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H190 R232 K235 D238 C240 Y241 D280 D287 H290
Catalytic site (residue number reindexed from 1) H184 R226 K229 D232 C234 Y235 D274 D281 H284
Enzyme Commision number 2.5.1.60: protein geranylgeranyltransferase type II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FPP B F147 H190 G192 C196 Y241 W244 F293 F141 H184 G186 C190 Y235 W238 F287 MOAD: Kd=94nM
PDBbind-CN: -logKd/Ki=7.03,Kd=94nM
BS02 ZN B D238 C240 H290 D232 C234 H284
BS03 CA B H64 M66 H58 M60
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004659 prenyltransferase activity
GO:0004661 protein geranylgeranyltransferase activity
GO:0004663 Rab geranylgeranyltransferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008318 protein prenyltransferase activity
GO:0019840 isoprenoid binding
GO:0031267 small GTPase binding
GO:0046872 metal ion binding
Biological Process
GO:0018344 protein geranylgeranylation
Cellular Component
GO:0005968 Rab-protein geranylgeranyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3dsu, PDBe:3dsu, PDBj:3dsu
PDBsum3dsu
PubMed18756270
UniProtQ08603|PGTB2_RAT Geranylgeranyl transferase type-2 subunit beta (Gene Name=Rabggtb)

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