Structure of PDB 3dls Chain B

Receptor sequence
>3dlsB (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
AVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIK
KEWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSG
LDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIA
EDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMW
SLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPE
RRTTLEKLVTDPWVTQPVNLADYTWEEVFR
3D structure
PDB3dls Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation.
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1128 K1130 E1132 N1133 D1146 L1153 T1165
Catalytic site (residue number reindexed from 1) D141 K143 E145 N146 D159 L166 T178
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B N1133 D1146 N146 D159
BS02 MG B P1098 E1199 P111 E212
BS03 ADP B L1005 G1006 V1013 V1026 K1028 I1065 H1084 G1087 D1089 V1135 I1145 D1146 L24 G25 V32 V45 K47 I78 H97 G100 D102 V148 I158 D159
BS04 MG B G1006 G1008 G25 G27
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3dls, PDBe:3dls, PDBj:3dls
PDBsum3dls
PubMed20943661
UniProtQ96RG2|PASK_HUMAN PAS domain-containing serine/threonine-protein kinase (Gene Name=PASK)

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