Structure of PDB 3dk7 Chain B

Receptor sequence
>3dk7B (length=269) Species: 10090 (Mus musculus) [Search protein sequence]
DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLMEVEEFLKE
AAVMKEIKHPNLVQLLGVCTREPPFYIIIEFMTYGNLLDYLRECNRQEVS
AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR
LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYG
MSPYPGIDPSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSF
AEIHQAFETMFQESSISDE
3D structure
PDB3dk7 Crystal structure of mutant ABL kinase domain in complex with small molecule fragment
ChainB
Resolution2.01 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D363 A365 R367 N368 D381 P402
Catalytic site (residue number reindexed from 1) D127 A129 R131 N132 D145 P166
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SX7 B L248 G249 Y253 A269 I315 F317 M318 G321 L370 L16 G17 Y21 A37 I79 F81 M82 G85 L134
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3dk7, PDBe:3dk7, PDBj:3dk7
PDBsum3dk7
PubMed
UniProtP00520|ABL1_MOUSE Tyrosine-protein kinase ABL1 (Gene Name=Abl1)

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