Structure of PDB 3dc2 Chain B

Receptor sequence

>3dc2B (length=523) Species: 1773 (Mycobacterium tuberculosis)

LPVVLIADKLAPSTVAALGDQVEVRWVDGPDRDKLLAAVPEADALLVRSA
TTVDAEVLAAAPKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSA
AEHALALLLAASRQIPAADASLREHTWKRSSFSGTEIFGKTVGVVGLGRI
GQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLLARADFISVH
LPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAITGGHVRA
AGLDVFATEPCTDSPLFELAQVVVTPHLGASTAEAQDRAGTDVAESVRLA
LAGEFVPDAVNVGGGVVNEEVAPWLDLVRKLGVLAGVLSDELPVSLSVQV
RGELAAEEVEVLRLSALRGLFSAVIETFVNAPALAAERGVTAEICKASES
PNHRSVVDVRAVGADGSVVTVSGTLYGPQLSQKIVQINGRHFDLRAQGIN
LIIHYVDRPGALGKIGTLLGTAGVNIQAAQLSEDAEGPGATILLRLDQDV
PDDVRTAIAAAVDAYKLEVVDLS

3D structure

• PDB: 3dc2 Structural analysis of substrate and effector binding in Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase
• Chain: B
• Resolution: 2.7 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): N99 R233 D257 E262 H280
• Catalytic site (residue number reindexed from 1): N96 R230 D254 E259 H277
• Enzyme Commision number: 1.1.1.399: 2-oxoglutarate reductase.
  1.1.1.95: phosphoglycerate dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SER	B	Y461 D463 R464	Y455 D457 R458

Gene Ontology

Molecular Function

• GO:0004617 phosphoglycerate dehydrogenase activity
• GO:0005515 protein binding
• GO:0016491 oxidoreductase activity
• GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
• GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
• GO:0051287 NAD binding

Biological Process

• GO:0006564 L-serine biosynthetic process

Cellular Component

• GO:0005886 plasma membrane
• GO:0009274 peptidoglycan-based cell wall

External links

• PDB: RCSB:3dc2, PDBe:3dc2, PDBj:3dc2
• PDBsum: 3dc2
• PubMed: 18627175
• UniProt: P9WNX3|SERA_MYCTU D-3-phosphoglycerate dehydrogenase (Gene Name=serA)