Structure of PDB 3da8 Chain B

Receptor sequence
>3da8B (length=205) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
PLRVPPSAPARLVVLASGTGSLLRSLLDAAVGDYPARVVAVGVDRECRAA
EIAAEASVPVFTVRLADHPSRDAWDVAITAATAAHEPDLVVSAGFMRILG
PQFLSRFYGRTLNTHPALLPAFPGTHGVADALAYGVKVTGATVHLVDADT
GPILAQQPVPVLDGDDEETLHERIKVTERRLLVAAVAALATHGVTVVGRT
ATMGR
3D structure
PDB3da8 Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery.
ChainB
Resolution1.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N116 H118 T145 D154
Catalytic site (residue number reindexed from 1) N113 H115 T142 D149
Enzyme Commision number 2.1.2.2: phosphoribosylglycinamide formyltransferase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IOD B G21 C50 G18 C47
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004644 phosphoribosylglycinamide formyltransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0009058 biosynthetic process
GO:0046653 tetrahydrofolate metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:3da8, PDBe:3da8, PDBj:3da8
PDBsum3da8
PubMed19394344
UniProtP9WHM5|PUR3_MYCTU Phosphoribosylglycinamide formyltransferase (Gene Name=purN)

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