Structure of PDB 3d57 Chain B

Receptor sequence
>3d57B (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
KPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIAPEGG
KVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEI
MSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFRLGMSLSS
FNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKH
HVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFE
3D structure
PDB3d57 Molecular basis for dimer formation of TRbeta variant D355R.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4HY B F272 I276 M313 A317 R320 L330 N331 G344 L346 M442 F60 I64 M101 A105 R108 L118 N119 G132 L134 M230 BindingDB: IC50=0.0407nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3d57, PDBe:3d57, PDBj:3d57
PDBsum3d57
PubMed18798561
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

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