Structure of PDB 3d45 Chain B

Receptor sequence
>3d45B (length=373) Species: 10090 (Mus musculus) [Search protein sequence]
GPMEIIRSNFKINLHKVYQAIEEADFFAIDGEFSGISDGPSVTALTSGFD
TPEERYQKLKKHSMDFLLFQFGLCAFKYDHTDSKHVTKSFNFYVFPKPFS
RSSPDVKFVCQSSSIDFLASQGFDFNKVFCSGIPYLNQEEERQLRETKEQ
EELNDAVGFSRVIHAIANSGKLVVGHNMLLDVMHTIHQFYCPLPADLNEF
KEMAICVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFDPPKVE
SAEHEAGYDAYITGLCFISMANYLGSKLIEPFFNKLFLMRIPYLNLEGPD
LQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTSAFVSLSQPE
QVQIAVNTSKYAESYRIQTYAEY
3D structure
PDB3d45 Structural basis of m(7)GpppG binding to poly(A)-specific ribonuclease.
ChainB
Resolution3.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.13.4: poly(A)-specific ribonuclease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7MG B W449 W468 D470 D471 W317 W336 D338 D339 PDBbind-CN: -logKd/Ki=5.68,Kd=2.1uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004535 poly(A)-specific ribonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006402 mRNA catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3d45, PDBe:3d45, PDBj:3d45
PDBsum3d45
PubMed19217398
UniProtQ8VDG3|PARN_MOUSE Poly(A)-specific ribonuclease PARN (Gene Name=Parn)

[Back to BioLiP]