Structure of PDB 3cwd Chain B

Receptor sequence
>3cwdB (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
SADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMM
GEDKIKQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVT
LLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEP
KFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQA
LELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLH
PLLQEIYKDL
3D structure
PDB3cwd Molecular recognition of nitrated fatty acids by PPAR gamma.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E298 K301 L311 Q314 V315 L318 K319 P467 L468 E471 E82 K85 L95 Q98 V99 L102 K103 P251 L252 E255
BS02 LNA B C285 R288 S289 H323 Y327 H449 C69 R72 S73 H107 Y111 H233
BS03 LNB B C285 R288 S289 H323 Y327 I341 H449 C69 R72 S73 H107 Y111 I125 H233 BindingDB: IC50=410nM,EC50=45nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3cwd, PDBe:3cwd, PDBj:3cwd
PDBsum3cwd
PubMed18604218
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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