Structure of PDB 3cmd Chain B

Receptor sequence
>3cmdB (length=188) Species: 1352 (Enterococcus faecium) [Search protein sequence]
SGLVPGRHMMITMDDIIREGNPTLREVAKEVSLPLSEEDISLGKEMLEFL
KNSQDPIKAEELHLRGGVGLAAPQLDISKRIIAVHVPSSLSTVMYNPKIL
SHSVQDACLGEGEGCLSVDREVPGYVVRHAKITVSYYDMNGEKHKIRLKN
YESIVVQHEIDHINGVMFYDHINDQNPFALKEGVLVIE
3D structure
PDB3cmd Insight into the antibacterial drug design and architectural mechanism of peptide recognition from the E. faecium peptide deformylase structure.
ChainB
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G60 Q65 C114 L115 H157 E158 H161
Catalytic site (residue number reindexed from 1) G69 Q74 C115 L116 H158 E159 H162
Enzyme Commision number 3.5.1.88: peptide deformylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE B Q65 C114 H157 H161 Q74 C115 H158 H162
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0042586 peptide deformylase activity
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0018206 peptidyl-methionine modification

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:3cmd, PDBe:3cmd, PDBj:3cmd
PDBsum3cmd
PubMed18831047
UniProtQ842S4

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