Structure of PDB 3cm7 Chain B

Receptor sequence
>3cm7B (length=101) Species: 9606 (Homo sapiens) [Search protein sequence]
NLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCG
GGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVR
T
3D structure
PDB3cm7 Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles.
ChainB
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C300 C303 H320 C327 C46 C49 H66 C73
BS02 X22 B K299 G306 L307 T308 D309 W310 E314 Q319 W323 K45 G52 L53 T54 D55 W56 E60 Q65 W69 PDBbind-CN: -logKd/Ki=6.57,IC50=270nM
BindingDB: IC50=290nM
External links
PDB RCSB:3cm7, PDBe:3cm7, PDBj:3cm7
PDBsum3cm7
PubMed18851976
UniProtP98170|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)

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