Structure of PDB 3clz Chain B

Receptor sequence
>3clzB (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
SNHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAG
GYEDDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFA
PINDQEGAEAKDWRSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKY
WPEKGKSGFLVWRYLLRRDDDEPGPWTKEGKDRIKKLGLTMQYPEGYLEA
LANAHHHHHH
3D structure
PDB3clz Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B F432 R433 V446 A447 G448 A463 G465 Y466 D469 Y478 T479 S481 R491 K540 F18 R19 V32 A33 G34 A49 G51 Y52 D55 Y64 T65 S67 R77 K126
BS02 dna B H445 H450 R452 S453 N489 R491 H31 H36 R38 S39 N75 R77
BS03 dna B F513 A514 P515 F99 A100 P101
External links
PDB RCSB:3clz, PDBe:3clz, PDBj:3clz
PDBsum3clz
PubMed18772889
UniProtQ96T88|UHRF1_HUMAN E3 ubiquitin-protein ligase UHRF1 (Gene Name=UHRF1)

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