Structure of PDB 3cld Chain B

Receptor sequence

>3cldB (length=241) Species: 9606 (Homo sapiens) [Search protein sequence]

LTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKW
AKAIPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQNLLCFAPDLIIN
EQRMTLPGMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGL
KSQELFDEIRMTYIKELGKAIVKRQNWQRFYQLTKLLDSMHEVVENLLNY
CFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ

3D structure

PDB

3cld X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocorticoid receptor-ligand binding domain.

Chain

Resolution

2.84 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	V575 K579 M593 M752 E755	V48 K52 M66 M217 E220
BS02	GW6	B	M560 L563 N564 G567 Q570 M601 M604 A605 F623 M639 C643 L732 Y735 C736 T739	M33 L36 N37 G40 Q43 M74 M77 A78 F93 M109 C113 L197 Y200 C201 T204	BindingDB: Ki=0.510000nM,IC50=0.0398nM,EC50=0.400000nM

External links

PDB	RCSB:3cld, PDBe:3cld, PDBj:3cld
PDBsum	3cld
PubMed	18522385
UniProt	P04150\|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

[Back to BioLiP]