Structure of PDB 3ckl Chain B

Receptor sequence
>3cklB (length=296) Species: 9606 (Homo sapiens) [Search protein sequence]
MLSPKDILRKDLKLVHGYPMTCAFASNWEKIEQFHSRPDDIVIATYPKSG
TTWVSEIIDMILNDGDIEKCKRGFITEKVPMLEMTLPGLRTSGIEQLEKN
PSPRIVKTHLPTDLLPKSFWENNCKMIYLARNAKDVSVSYYHFDLMNNLQ
PFPGTWEEYLEKFLTGKVAYGSWFTHVKNWWKKKEEHPILFLYYEDMKEN
PKEEIKKIIRFLEKNLNDEILDRIIHHTSFEVMKDNPLVNYTHLPTTVMD
HSKSPFMRKGTAGDWKNYFTVAQNEKFDAIYETEMSKTALQFRTEI
3D structure
PDB3ckl Crystal structure of human cytosolic sulfotransferase SULT1B1 in complex with PAP and resveratrol.
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K48 H109 S139
Catalytic site (residue number reindexed from 1) K48 H109 S139
Enzyme Commision number 2.8.2.1: aryl sulfotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STL B F24 M81 H109 F143 N147 L244 V248 F24 M81 H109 F143 N147 L244 V248
BS02 A3P B K48 G50 T51 T52 W53 R131 S139 Y194 F230 F256 M257 R258 K259 G260 K48 G50 T51 T52 W53 R131 S139 Y194 F230 F256 M257 R258 K259 G260
Gene Ontology
Molecular Function
GO:0004062 aryl sulfotransferase activity
GO:0005515 protein binding
GO:0008146 sulfotransferase activity
GO:0016740 transferase activity
Biological Process
GO:0006068 ethanol catabolic process
GO:0006576 biogenic amine metabolic process
GO:0006805 xenobiotic metabolic process
GO:0009812 flavonoid metabolic process
GO:0018958 phenol-containing compound metabolic process
GO:0030855 epithelial cell differentiation
GO:0042403 thyroid hormone metabolic process
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923 sulfation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:3ckl, PDBe:3ckl, PDBj:3ckl
PDBsum3ckl
PubMed
UniProtO43704|ST1B1_HUMAN Sulfotransferase 1B1 (Gene Name=SULT1B1)

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