Structure of PDB 3c8z Chain B

Receptor sequence
>3c8zB (length=401) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
HMMQSWSAPAIPVVPGRGPALRLFDSADRQVRPVTPGPTATMYVCGITPY
DATHLGHAATYLTFDLVHRLWLDAGHTVQYVQNVTDVDDPLFERAERDGI
DWRTLGDRETQLFREDMAALRVLPPHDYVAATDAIAEVVEMVEKLLASGA
AYIVEDAEYPDVYFRADATAQFGYESGYDRDTMLTLFAERGGDPDRPGKS
DQLDALLWRAERPGEPSWPSPFGRGRPGWHVECSAIALTRIGTGLDIQGG
GSDLIFPHHEYSAAHAESVTGERRFARHYVHTGMIGVLVSQLRAQGVDPS
AIRLGLFSGHYREDRFWSNEVLDEANARLARWRSATALPEAPDATDVIAR
VRQYLADDLDTPKALAALDGWCTDALSYGGHDTESPRLVATTVDALLGVD
L
3D structure
PDB3c8z The 1.6 A crystal structure of Mycobacterium smegmatis MshC: the penultimate enzyme in the mycothiol biosynthetic pathway.
ChainB
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.1.13: L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C43 C231 H256 C45 C233 H258
BS02 5CA B C43 G44 I45 T46 H52 G54 H55 T58 Y59 T83 W227 G249 D251 L252 M282 I283 C45 G46 I47 T48 H54 G56 H57 T60 Y61 T85 W229 G251 D253 L254 M284 I285 MOAD: Ki=300nM
Gene Ontology
Molecular Function
GO:0004817 cysteine-tRNA ligase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0035446 cysteine-glucosaminylinositol ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006423 cysteinyl-tRNA aminoacylation
GO:0010125 mycothiol biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3c8z, PDBe:3c8z, PDBj:3c8z
PDBsum3c8z
PubMed19053270
UniProtA0QZY0|MSHC_MYCS2 L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase (Gene Name=mshC)

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