Structure of PDB 3c6m Chain B

Receptor sequence
>3c6mB (length=342) Species: 9606 (Homo sapiens) [Search protein sequence]
SRHSTLDFMLGETILKGLQSIFQEQGMAESVHTWQDHGYLATYTNKNGSF
ANLRIYPHGLVLLDLQSGKEEIDSILNKVEERMKELSRVKRLPPIVRGGA
IDRYWPTADGRLVEYDIDEVVYDEDSPYQNIKILHSKQFGNILILSGDVN
LAESDLAYTRAIMGSGKEDYTGKDVLILGGGDGGILCEIVKLKPKMVTMV
EIDQMVIDGCKKYMRKTCGDVLDNLKGDCYQVLIEDCIPVLKRYAKEGRE
FDYVINDLTAVPISTSSTWEFLRLILDLSMKVLKQDGKYFTQGNCVNLTE
ALSLYEEQLGRLYCPVEFSKEIVCVPSYLELWVFYTVWKKAK
3D structure
PDB3c6m Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism.
ChainB
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.22: spermine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SPM B D167 V168 N169 Y177 D201 D276 L277 Q315 Y351 E353 W355 D148 V149 N150 Y158 D182 D257 L258 Q292 Y328 E330 W332
BS02 MTA B Q148 L164 N169 G198 G199 D201 E220 I221 V225 C256 D276 L277 T278 I282 Q129 L145 N150 G179 G180 D182 E201 I202 V206 C237 D257 L258 T259 I263 MOAD: Ki=0.3uM
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0016768 spermine synthase activity
Biological Process
GO:0006555 methionine metabolic process
GO:0006595 polyamine metabolic process
GO:0006596 polyamine biosynthetic process
GO:0006597 spermine biosynthetic process
GO:0008215 spermine metabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3c6m, PDBe:3c6m, PDBj:3c6m
PDBsum3c6m
PubMed18367445
UniProtP52788|SPSY_HUMAN Spermine synthase (Gene Name=SMS)

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