Structure of PDB 3c6g Chain B

Receptor sequence
>3c6gB (length=467) Species: 9606 (Homo sapiens) [Search protein sequence]
FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVV
LNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRR
LAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVS
NITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGIL
PFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGK
NDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQK
EIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAV
VRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEAL
VPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMT
LQPQPYLICAERRHHHH
3D structure
PDB3c6g Structural analysis of CYP2R1 in complex with vitamin D3.
ChainB
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T314 F441 C448
Catalytic site (residue number reindexed from 1) T276 F403 C410
Enzyme Commision number 1.14.14.24: vitamin D 25-hydroxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B R109 L125 W133 R137 F144 A310 G311 T314 H381 P440 F441 S442 R446 C448 G450 A454 R71 L87 W95 R99 F106 A272 G273 T276 H343 P402 F403 S404 R408 C410 G412 A416
BS02 VD3 B F214 A250 V253 F302 G305 F176 A212 V215 F264 G267
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008395 steroid hydroxylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0020037 heme binding
GO:0030343 vitamin D3 25-hydroxylase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:1902271 D3 vitamins binding
Biological Process
GO:0006082 organic acid metabolic process
GO:0006629 lipid metabolic process
GO:0006766 vitamin metabolic process
GO:0006805 xenobiotic metabolic process
GO:0010038 response to metal ion
GO:0010164 response to cesium ion
GO:0010212 response to ionizing radiation
GO:0036378 calcitriol biosynthetic process from calciol
GO:0042359 vitamin D metabolic process
GO:0042368 vitamin D biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3c6g, PDBe:3c6g, PDBj:3c6g
PDBsum3c6g
PubMed18511070
UniProtQ6VVX0|CP2R1_HUMAN Vitamin D 25-hydroxylase (Gene Name=CYP2R1)

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