Structure of PDB 3c4m Chain B

Receptor sequence

>3c4mB (length=469) Species: 9606,83333

EGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAAT
GDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKL
IAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQE
PYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKH
MNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQ
PSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVA
LKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASG
RQTVDEALKDAQTNAAAEFDDVMTKEEQIFLLHRAQAQCEKRLKEVLQGR
PCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWEL
VPGHNRTWANYSECVKFLT

3D structure

• PDB: 3c4m Molecular recognition of parathyroid hormone by its G protein-coupled receptor.
• Chain: B
• Resolution: 1.95 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	D29 D30 M32 K34 Q37 I38 L41 E111 W112 D113 H114 I115 I135 Y136 D137 R146 R162 T163 Y167	D370 D371 M373 K375 Q378 I379 L382 E405 W406 D407 H408 I409 I429 Y430 D431 R440 R456 T457 Y461
BS02	GLC	B	D-330 K-329 E-233 F-188 W-114	D11 K12 E108 F153 W227
BS03	GLC	B	W-282 D-279 R-278 E-191 P-190 Y-189 W-4 R0	W59 D62 R63 E150 P151 Y152 W337 R341

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0015144 carbohydrate transmembrane transporter activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0008643 carbohydrate transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:3c4m, PDBe:3c4m, PDBj:3c4m
• PDBsum: 3c4m
• PubMed: 18375760
• UniProt: P0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
  Q03431|PTH1R_HUMAN Parathyroid hormone/parathyroid hormone-related peptide receptor (Gene Name=PTH1R)