Structure of PDB 3c33 Chain B

Receptor sequence
>3c33B (length=254) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDV
KLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSK
PFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKIST
YEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCN
LTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRG
NGCP
3D structure
PDB3c33 Molecular basis of kainate receptor modulation by sodium.
ChainB
Resolution1.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K B E96 K97 I99 D100 E93 K94 I96 D97
BS02 KAI B Y61 P88 T90 R95 G140 S141 T142 E190 Y58 P85 T87 R92 G137 S138 T139 E187 BindingDB: IC50=77nM,Ki=75.9nM,EC50=37000nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:3c33, PDBe:3c33, PDBj:3c33
PDBsum3c33
PubMed18549784
UniProtP22756|GRIK1_RAT Glutamate receptor ionotropic, kainate 1 (Gene Name=Grik1)

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