Structure of PDB 3c16 Chain B

Receptor sequence
>3c16B (length=186) Species: 10116 (Rattus norvegicus) [Search protein sequence]
HQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSK
PKFSGVEKIKTIGSTYMAATGLSQYMHIGTMVEFAYALVGKLDAINKHSF
NDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQV
TEETSLILQTLGYTCTCRGIINVKGKGDLKTYFVNT
3D structure
PDB3c16 Structural basis for inhibition of mammalian adenylyl cyclase by calcium.
ChainB
Resolution2.87 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S891 I892 S942 R1029 K1065
Catalytic site (residue number reindexed from 1) S13 I14 S64 R138 K174
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FOK B Y899 I940 G941 S942 Y21 I62 G63 S64
Gene Ontology
Molecular Function
GO:0016849 phosphorus-oxygen lyase activity
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:3c16, PDBe:3c16, PDBj:3c16
PDBsum3c16
PubMed19243146
UniProtP26769|ADCY2_RAT Adenylate cyclase type 2 (Gene Name=Adcy2)

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