Structure of PDB 3bqn Chain B

Receptor sequence
>3bqnB (length=182) Species: 9606 (Homo sapiens) [Search protein sequence]
GNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSY
KTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGAR
PDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKF
ASKPASEFVKILDTFEKLKDLFTELQKKIYVI
3D structure
PDB3bqn Structure-activity relationship of ortho- and meta-phenol based LFA-1 ICAM inhibitors
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BQN B F153 V157 Y166 I235 Y257 I259 F285 K287 E301 L302 K305 F26 V30 Y39 I108 Y130 I132 F158 K160 E174 L175 K178 MOAD: ic50=2.5nM
PDBbind-CN: -logKd/Ki=8.60,IC50=2.5nM
BindingDB: IC50=2.5nM
External links
PDB RCSB:3bqn, PDBe:3bqn, PDBj:3bqn
PDBsum3bqn
PubMed18783948
UniProtP20701|ITAL_HUMAN Integrin alpha-L (Gene Name=ITGAL)

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