Structure of PDB 3bpr Chain B

Receptor sequence
>3bprB (length=256) Species: 9606 (Homo sapiens) [Search protein sequence]
KLEDVVIDRNLLILGKILGEEFGSVMEGNLKQEDGTSLKVAVKTMKLIEE
FLSEAACMKDFSHPNVIRLLGVCIEMPMVILPFMKYGDLHTYLLYSRLET
GPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVA
DFGLSPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNH
EMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKL
LESLPD
3D structure
PDB3bpr Structural insights into the inhibited states of the Mer receptor tyrosine kinase.
ChainB
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D723 A725 R727 N728 D741
Catalytic site (residue number reindexed from 1) D133 A135 R137 N138 D151
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OLP B V601 A617 F673 M674 K675 G677 M730 V25 A41 F83 M84 K85 G87 M140
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:3bpr, PDBe:3bpr, PDBj:3bpr
PDBsum3bpr
PubMed19028587
UniProtQ12866|MERTK_HUMAN Tyrosine-protein kinase Mer (Gene Name=MERTK)

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