Structure of PDB 3bpm Chain B

Receptor sequence
>3bpmB (length=232) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
EANYEDVIKKYKPADAKLDRIAYDWRLHGGVTPVKDQALCGSCWAFSSVG
SVESQYAIRKKALFLFSEQELVDCSVKNNGCYGGYITNAFDDMIDLGGLC
SQDDYPYVSNLPETCNLKRCNERYTIKSYVSIPDDKFKEALRYLGPISIS
IAASDDFAFYRGGFYDGECGAAPNHAVILVGYGMKDEKFYYYIIKNSWGS
DWGEGGYINLETDENGYKKTCSIGTEAYVPLL
3D structure
PDB3bpm Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity.
ChainB
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q45 C51 H183 N213
Catalytic site (residue number reindexed from 1) Q37 C43 H175 N196
Enzyme Commision number 3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B G49 C51 Y90 G91 G92 Y93 N182 H183 G41 C43 Y82 G83 G84 Y85 N174 H175
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3bpm, PDBe:3bpm, PDBj:3bpm
PDBsum3bpm
PubMed19128015
UniProtQ8IIL0|FPC3_PLAF7 Falcipain-3 (Gene Name=FP3)

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