Structure of PDB 3bla Chain B

Receptor sequence
>3blaB (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
VRLPFSGFRLQKVLRESARDKIIFLHGKVNEDAVVILEKTPFQVEQVAQL
LTGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPATEKHLQKYLRQD
LRLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRIVFENPDPS
DGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILHQ
GQEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHL
LAEVIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQ
3D structure
PDB3bla DcpS as a therapeutic target for spinal muscular atrophy.
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.59: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DD3 B W175 E185 D205 L206 W128 E138 D158 L159 PDBbind-CN: -logKd/Ki=8.70,Ki=2nM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
Biological Process
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA

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Molecular Function
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Biological Process
External links
PDB RCSB:3bla, PDBe:3bla, PDBj:3bla
PDBsum3bla
PubMed18839960
UniProtQ96C86|DCPS_HUMAN m7GpppX diphosphatase (Gene Name=DCPS)

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