Structure of PDB 3bgd Chain B

Receptor sequence
>3bgdB (length=232) Species: 10090 (Mus musculus) [Search protein sequence]
PDAEVQKNQVLTLEDWKEKWVTRHISFHQEQGHQLLKKHLDTFLKGQSGL
RVFFPLCGKAIEMKWFADRGHTVVGVEISEIGIREFFAEQNLSYTEEPLA
EIAGAKVFKSSSGSISLYCCSIFDLPRANIGKFDRIWDRGALVAINPGDH
DRYADIILSLLRKEFQYLVAVLSYDPTKHAGPPFYVPSAELKRLFGTKCS
MQCLEEVDALEERHKAWGLDYLFEKLYLLTEK
3D structure
PDB3bgd Structural Basis of Substrate Recognition in Thiopurine S-Methyltransferase
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.67: thiopurine S-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B L21 W24 W28 F35 L64 C65 E85 I86 S129 I130 R147 G148 L13 W16 W20 F27 L56 C57 E77 I78 S121 I122 R139 G140
BS02 PM6 B F35 R147 G148 P191 R221 F27 R139 G140 P183 R213
BS03 PM6 B H47 T50 F51 L212 L236 H39 T42 F43 L204 L228
Gene Ontology
Molecular Function
GO:0008119 thiopurine S-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
Biological Process
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3bgd, PDBe:3bgd, PDBj:3bgd
PDBsum3bgd
PubMed18484748
UniProtO55060|TPMT_MOUSE Thiopurine S-methyltransferase (Gene Name=Tpmt)

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