Structure of PDB 3b99 Chain B

Receptor sequence
>3b99B (length=415) Species: 7955 (Danio rerio) [Search protein sequence]
RRTRRRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAG
LYITVLLDSNCYDAVLSDVASLDQTSYAQVLMKRIFNMILPSHNPESEKK
RAEMHFQGASLTQLSNSMQNNLRLLMTPSEMWKKDGLFNLCYSLLFKTGY
LTVFTQIYEEFRRFDKLLPKLARTEKQIASAAREKLWKWLTSWLGSYVKQ
LQDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREE
IQNTPVFDSVLWETLRLTAAALITRDVTQDKKICLSNGQEYHLRRGDRLC
VFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKNGARVKYPSVPW
GTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFG
ILQPAGDLEIRYRIR
3D structure
PDB3b99 Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.152: hydroperoxy icosatetraenoate dehydratase.
5.3.99.4: prostaglandin-I synthase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008116 prostaglandin-I synthase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016829 lyase activity
GO:0016853 isomerase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0106256 hydroperoxy icosatetraenoate dehydratase activity
Biological Process
GO:0001516 prostaglandin biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3b99, PDBe:3b99, PDBj:3b99
PDBsum3b99
PubMed18032380
UniProtF1RE08|PTGIS_DANRE Prostacyclin synthase (Gene Name=ptgis)

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