Structure of PDB 3b98 Chain B

Receptor sequence
>3b98B (length=427) Species: 7955 (Danio rerio) [Search protein sequence]
RTRRRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGL
YITVLLDSNCYDAVLSDVASLDQTSYAQVLMKRIFNMILPSHNPESEKKR
AEMHFQGASLTQLSNSMQNNLRLLMTPSEMGLKWKKDGLFNLCYSLLFKT
GYLTVFGASAALTQIYEEFRRFDKLLPKLARTTVNKEEKQIASAAREKLW
KWLSWLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLL
THPEALRAVREEIQNTPVFDSVLWETLRLTAAALITRDVTQDKKICLSNG
QEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFK
NGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNAT
VPLVDPSRYGFGILQPAGDLEIRYRIR
3D structure
PDB3b98 Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change
ChainB
Resolution2.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.152: hydroperoxy icosatetraenoate dehydratase.
5.3.99.4: prostaglandin-I synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B Q94 F126 V273 T274 N277 A278 P413 W414 C421 P422 G423 F426 A427 I465 Q73 F105 V233 T234 N237 A238 P361 W362 C369 P370 G371 F374 A375 I413
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008116 prostaglandin-I synthase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016829 lyase activity
GO:0016853 isomerase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0106256 hydroperoxy icosatetraenoate dehydratase activity
Biological Process
GO:0001516 prostaglandin biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:3b98, PDBe:3b98, PDBj:3b98
PDBsum3b98
PubMed18032380
UniProtF1RE08|PTGIS_DANRE Prostacyclin synthase (Gene Name=ptgis)

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