Structure of PDB 3b95 Chain B

Receptor sequence
>3b95B (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]
RSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVK
YLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGG
WTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAE
ILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGE
TPLQCASLNSQVWSALQMSKALQDS
3D structure
PDB3b95 The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules.
ChainB
Resolution2.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K817 K818 W843 W848 Y852 H854 E874 N876 W881 F884 K75 K76 W101 W106 Y110 H112 E132 N134 W139 F142
Gene Ontology
Molecular Function
GO:0002039 p53 binding
GO:0016279 protein-lysine N-methyltransferase activity
GO:0042054 histone methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:3b95, PDBe:3b95, PDBj:3b95
PDBsum3b95
PubMed18264113
UniProtQ9H9B1|EHMT1_HUMAN Histone-lysine N-methyltransferase EHMT1 (Gene Name=EHMT1)

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