Structure of PDB 3b6r Chain B

Receptor sequence
>3b6rB (length=376) Species: 9606 (Homo sapiens) [Search protein sequence]
SHNALKLRFPAEDEFPDLSAHNNHMAKVLTPELYAELRAKSTPSGFTLDD
VIQTGVDNPGHPYIMTVGCVAGDEESYEVFKDLFDPIIEDRHGGYKPSDE
HKTDLNPDNLQGGDDLDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIE
KLAVEALSSLDGDLAGRYYALKSMTEAEQQQLIDDHFLFDKPVSPLLLAS
GMARDWPDARGIWHNDNKTFLVWVNEEDHLRVISMQKGGNMKEVFTRFCT
GLTQIETLFKSKDYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLPNLGKH
EKFSEVLKRLRLQKRGTGGVDTAAVGGVFDVSNADRLGFSEVELVQMVVD
GVKLLIEMEQRLEQGQAIDDLMPAQK
3D structure
PDB3b6r Structural studies of human brain-type creatine kinase complexed with the ADP-Mg2+-NO3- -creatine transition-state analogue complex
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R132 E232 R236 C283 S285 R292 R320 V325
Catalytic site (residue number reindexed from 1) R127 E227 R231 C278 S280 R287 R315 V320
Enzyme Commision number 2.7.3.2: creatine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NO3 B R132 R236 R320 R127 R231 R315
BS02 ADP B S128 R130 R132 H191 M240 R292 V295 H296 R320 G323 G324 V325 D335 S123 R125 R127 H186 M235 R287 V290 H291 R315 G318 G319 V320 D330
BS03 CRN B T71 V72 L201 E232 C283 T66 V67 L196 E227 C278
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004111 creatine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0016310 phosphorylation
GO:0021762 substantia nigra development
GO:0046314 phosphocreatine biosynthetic process
GO:0140651 futile creatine cycle
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3b6r, PDBe:3b6r, PDBj:3b6r
PDBsum3b6r
PubMed18977227
UniProtP12277|KCRB_HUMAN Creatine kinase B-type (Gene Name=CKB)

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