Structure of PDB 3b2t Chain B

Receptor sequence
>3b2tB (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
PMLAGVSEYELPEDPKWEFPRDKLTLGKPLFGQVVMAEAVGIDKPKEAVT
VAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVI
VEYASKGNLREYLRARRPPQMTFKDLVSCTYQLARGMEYLASQKCIHRDL
TARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFD
RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAN
CTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT
3D structure
PDB3b2t Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation.
ChainB
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D626 T628 R630 N631 D644
Catalytic site (residue number reindexed from 1) D149 T151 R153 N154 D167
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 M33 B L487 V495 A515 A567 L633 L30 V34 A52 A104 L156 PDBbind-CN: -logKd/Ki=5.21,Kd=6.21uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3b2t, PDBe:3b2t, PDBj:3b2t
PDBsum3b2t
PubMed18056630
UniProtP21802|FGFR2_HUMAN Fibroblast growth factor receptor 2 (Gene Name=FGFR2)

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