Structure of PDB 3b2r Chain B

Receptor sequence
>3b2rB (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
RELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQN
FQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNK
LTDLEILALLIAALSHDLDHRGCHSIMEHHHFDQCLMILNSPGNQILSGL
SIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKEL
FLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQKKNKIPSMQVGFIDA
ICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQ
3D structure
PDB3b2r Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil.
ChainB
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VDN B Y612 C677 I680 M816 Q817 F820 Y75 C123 I126 M243 Q244 F247 BindingDB: IC50=0.890000nM,Ki=1nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:3b2r, PDBe:3b2r, PDBj:3b2r
PDBsum3b2r
PubMed17959709
UniProtO76074|PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (Gene Name=PDE5A)

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