Structure of PDB 3ask Chain B

Receptor sequence
>3askB (length=211) Species: 9606 (Homo sapiens) [Search protein sequence]
SLYKVNEYVDARDTNMGAWFEAQVVRVTRKEDVIYHVKYDDYPENGVVQM
NSRDVRARARTIIKWQDLEVGQVVMLNYNPDNPKERGFWYDAEISRKRET
RTARELYANVVLGDDSLNDCRIIFVDEVFKIERPGEGSPMVDNPMRRKSG
PSCKHCKDDVNRLCRVCACHLCGGRQDPDKQLMCDECDMAFHIYCPLSSV
PSEDEWYCPEC
3D structure
PDB3ask Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1
ChainB
Resolution2.904 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B F152 Y188 D190 Y191 E193 Q330 L331 M332 D337 D356 F20 Y39 D41 Y42 E44 Q181 L182 M183 D188 D204
BS02 ZN B C302 C305 C313 C316 C153 C156 C164 C167
BS03 ZN B C318 H341 C169 H192
BS04 ZN B C333 C336 C184 C187
External links
PDB RCSB:3ask, PDBe:3ask, PDBj:3ask
PDBsum3ask
PubMed22837395
UniProtQ96T88|UHRF1_HUMAN E3 ubiquitin-protein ligase UHRF1 (Gene Name=UHRF1)

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