Structure of PDB 3ao2 Chain B

Receptor sequence
>3ao2B (length=134) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
SPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAG
RWPVKTVHTDNGSNFTGATVRAACDWAGIKQESMNKELKKIIGQVRDQAE
HLKTAVQMAVFIHNHKRGYSAGERIVDIIATDIQ
3D structure
PDB3ao2 Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AVX B G106 R107 W108 P109 G50 R51 W52 P53 MOAD: Kd=0.17mM
PDBbind-CN: -logKd/Ki=3.77,Kd=0.17mM
BS02 AVX B H185 R187 G197 E198 V201 H115 R117 G122 E123 V126 MOAD: Kd=0.17mM
PDBbind-CN: -logKd/Ki=3.77,Kd=0.17mM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3ao2, PDBe:3ao2, PDBj:3ao2
PDBsum3ao2
PubMed21275048
UniProtP04585|POL_HV1H2 Gag-Pol polyprotein (Gene Name=gag-pol)

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