Structure of PDB 3ao1 Chain B

Receptor sequence
>3ao1B (length=142) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
SPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAG
RWPVKTVHTDNGSNFTSTTVKAACDWAGIKQEGVIESMNKELKKIIGQVR
DQAEHLKTAVQMAVFIHNHKRKGGIGGYSAGERIVDIIATDI
3D structure
PDB3ao1 Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BZX B G106 R107 P109 G50 R51 P53 MOAD: Kd=5.5mM
PDBbind-CN: -logKd/Ki=2.26,Kd=5.5mM
BS02 BZX B H185 G197 H119 G131 MOAD: Kd=5.5mM
PDBbind-CN: -logKd/Ki=2.26,Kd=5.5mM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:3ao1, PDBe:3ao1, PDBj:3ao1
PDBsum3ao1
PubMed21275048
UniProtQ72498

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