Structure of PDB 3a9z Chain B

Receptor sequence
>3a9zB (length=399) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTAR
ASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQTRPHFITCTVEH
DSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIML
ANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDV
EDLGVDFLTIVGHKFYGPRIGALYVRGVGKLTPLYPMLFGGGQERNFRPG
TENTPMIAGLGKAADLVSENCETYEAHMRDIRDYLEERLEAEFGKRIHLN
SRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLLASVGASCHSDHEDRP
SPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQAVNQLEGPV
3D structure
PDB3a9z Reaction mechanism and molecular basis for selenium/sulfur discrimination of selenocysteine lyase.
ChainB
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.4.1.16: selenocysteine lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP B T88 H133 D221 A223 Q224 H246 K247 T71 H100 D188 A190 Q191 H213 K214
BS02 SLP B A26 N186 K247 A373 S374 R402 A9 N153 K214 A340 S341 R369
Gene Ontology
Molecular Function
GO:0009000 selenocysteine lyase activity
GO:0016597 amino acid binding
GO:0016740 transferase activity
GO:0016829 lyase activity
GO:0042803 protein homodimerization activity
GO:0070279 vitamin B6 binding
Biological Process
GO:0001887 selenium compound metabolic process
GO:0006629 lipid metabolic process
GO:0016261 selenocysteine catabolic process
GO:0032868 response to insulin
GO:1900408 negative regulation of cellular response to oxidative stress
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:1902494 catalytic complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3a9z, PDBe:3a9z, PDBj:3a9z
PDBsum3a9z
PubMed20164179
UniProtQ68FT9|SCLY_RAT Selenocysteine lyase (Gene Name=Scly)

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