Structure of PDB 3a06 Chain B

Receptor sequence
>3a06B (length=373) Species: 2336 (Thermotoga maritima) [Search protein sequence]
EERTLVILGATGSIGTQTLDVLKKVKGIRLIGISFHSNLELAFKIVKEFN
VKNVAITGDVEFEDSSINVWKGSHSIEEMLEALKPDITMVAVSGFSGLRA
VLASLEHSKRVCLANKESLVCGGFLVKKKLKEKGTELIPVDSEHSAIFQV
MEPEVEKVVLTASGGALRDWKISKIDRARPEDVLKHPVWNMGARITVDSA
TMVNKAFEVLEAMELFELPFEKIEVKIHREGLVHGAVVLPDGNVKMVVSP
PDMRIPISYALFYPRRVALEPFFLRTISLSFEDPDPEKYPAFFLLKEIKD
SYALRTAFNAADEVAVEAFLKGRIRFGGIHRVIEKTLEEFQGYPQPRTLD
DVERIHFEAIKKAERVTEWLSST
3D structure
PDB3a06 Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.267: 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP B G10 T12 G13 S14 I15 H37 S38 N39 T58 A92 V93 S94 S97 A115 I196 M254 G9 T11 G12 S13 I14 H36 S37 N38 T57 A91 V92 S93 S96 A114 I195 M253
BS02 FOM B A163 S164 S200 K206 A162 S163 S199 K205 MOAD: ic50~100nM
BS03 MG B D142 E144 E209 D141 E143 E208
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0030145 manganese ion binding
GO:0030604 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GO:0046872 metal ion binding
GO:0070402 NADPH binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
GO:0051484 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3a06, PDBe:3a06, PDBj:3a06
PDBsum3a06
PubMed20353826
UniProtQ9WZZ1|DXR_THEMA 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Gene Name=dxr)

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