Structure of PDB 2zx6 Chain B

Receptor sequence
>2zx6B (length=442) Species: 2336 (Thermotoga maritima) [Search protein sequence]
RYKPDWESLREHTVPKWFDKAKFGIFIHWGIYSVPGWATPTGELGKVPMD
AWFFQNPYAEWYENSLRIKESPTWEYHVKTYGENFEYEKFADLFTAEKWD
PQEWADLFKKAGAKYVIPTTKHHDGFCLWGTKYTDFNSVKRGPKRDLVGD
LAKAVREAGLRFGVYYSGGLDWRFTTEPIRYPEDLSYIRPNTYEYADYAY
KQVMELVDLYLPDVLWNDMGWPEKGKEDLKYLFAYYYNKHPEGSVNDRWG
VPHWDFKTAEYHVNYPGDLPGYKWEFTRGIGLSFGYNRNEGPEHMLSVEQ
LVYTLVDVVSKGGNLLLNVGPKGDGTIPDLQKERLLGLGEWLRKYGDAIY
GTSVWERCCAKTEDGTEIRFTRKCNRIFVIFLGIPTGEKIVIEDLNLSAG
TVRHFLTGERLSFKNVGKNLEITVPKKLLETDSITLVLEAVE
3D structure
PDB2zx6 Structural basis of alpha-fucosidase inhibition by iminocyclitols with K(i) values in the micro- to picomolar range.
ChainB
Resolution2.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.51: alpha-L-fucosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZX6 B H34 Y64 E66 W67 H128 H129 D224 M225 R254 E266 F290 H28 Y58 E60 W61 H122 H123 D218 M219 R248 E260 F284 MOAD: Ki=0.475nM
PDBbind-CN: -logKd/Ki=10.60,Ki=25.1pM
Gene Ontology
Molecular Function
GO:0004560 alpha-L-fucosidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006004 fucose metabolic process
GO:0016139 glycoside catabolic process
Cellular Component
GO:0005764 lysosome

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Cellular Component
External links
PDB RCSB:2zx6, PDBe:2zx6, PDBj:2zx6
PDBsum2zx6
PubMed19967696
UniProtQ9WYE2

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