Structure of PDB 2zwo Chain B

Receptor sequence
>2zwoB (length=393) Species: 311400 (Thermococcus kodakarensis) [Search protein sequence]
EQNTIRVIVSVDKAKFNPHEVLGIGGHIVYQFKLIPAVVVDVPANAVGKL
KKMPGVEKVEFDHQAVLLGKPSWSTQPAQTIPWGIERVKAPSVWSITDGS
VSVIQVAVLDTGVDYDHPDLAANIAWCVSTLRGKVSTKLRDCADQNGHGT
HVIGTIAALNNDIGVVGVAPGVQIYSVRVLDARGSGSYSDIAIGIEQAIL
GPDGVADKDGDGIIAGDPDDAAAEVISMSLGGPADDSYLYDMIIQAYNAG
IVIVAASGNEGAPSPSYPAAYPEVIAVGAIDSNDNIASFSNRQPEVSAPG
VDILSTYPDDSYETLMGTAMATPHVSGVVALIQAAYYQKYGKILPVGTFD
DISKNTVRGILHITADDLGPTGWDADYGYGVVRAALAVQAALG
3D structure
PDB2zwo Requirement of a unique Ca(2+)-binding loop for folding of Tk-subtilisin from a hyperthermophilic archaeon.
ChainB
Resolution2.07 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D115 H153 N264 A324
Catalytic site (residue number reindexed from 1) D110 H148 N259 A319
Enzyme Commision number 3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B Q84 D124 L164 N166 I168 V170 Q79 D119 L159 N161 I163 V165
BS02 CA B D212 D214 D216 I218 D222 D225 D207 D209 D211 I213 D217 D220
BS03 CA B D214 D216 D222 D224 D209 D211 D217 D219
BS04 CA B D372 L373 P375 G377 D379 D367 L368 P370 G372 D374
BS05 CA B V108 Q110 A227 E229 V103 Q105 A222 E224
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0042802 identical protein binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2zwo, PDBe:2zwo, PDBj:2zwo
PDBsum2zwo
PubMed19813760
UniProtP58502|TKSU_THEKO Tk-subtilisin (Gene Name=TK1675)

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